Best Online Direct Entry MSN Programs for Non-Nurses for 2025

by Imed Bouchrika, Phd

Co-Founder and Chief Data Scientist

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What can I expect from online direct entry MSN programs for non-nurses?

Online direct-entry MSN programs are designed to take non-nurses from foundational nursing knowledge to advanced practice in a condensed, intensive format. Most programs begin with a pre-licensure phase, where you’ll study core nursing subjects like anatomy, pharmacology, and clinical practice.

After passing the NCLEX-RN exam and earning your RN license, you'll move into the graduate-level coursework, which focuses on advanced topics such as healthcare leadership, population health, and your chosen specialization (e.g., family nurse practitioner or nurse educator).

While the coursework is primarily online, expect to complete in-person clinical hours and possibly on-campus intensives, depending on the school. These hands-on components are essential for gaining real-world experience and meeting licensure requirements.

Programs typically take 2 to 3 years to complete, depending on whether you study full-time or part-time. Overall, you can expect a rigorous but rewarding experience that prepares you to deliver high-quality care and take on leadership roles in the healthcare system.

Where can I work with an online direct-entry MSN degree?

Earning an online MSN degree prepares you for a variety of advanced roles in the healthcare field, far beyond traditional bedside nursing. Whether you’re interested in clinical practice, education, administration, or public health, an MSN equips you with the skills and credentials to thrive in multiple settings.

• Hospitals and Medical Centers: Work as a nurse practitioner, clinical nurse specialist, or nurse administrator in inpatient or outpatient care settings.
• Private Practices and Clinics: Provide primary or specialized care in roles like family nurse practitioner or women's health nurse practitioner.
• Community Health Organizations: Address population health needs, promote wellness, and manage care for underserved communities.
• Academic Institutions: Teach nursing students and contribute to curriculum development as a nurse educator.
• Telehealth and Remote Care: Offer virtual patient consultations, expanding access to healthcare services.
• Public Health and Government Agencies: Influence healthcare policy, lead community health programs, or work in disaster preparedness.
• Healthcare Administration: Oversee teams, manage operations, and drive improvements in quality and efficiency within healthcare systems.
• Research and Innovation: Contribute to clinical studies, health technology projects, or evidence-based practice initiatives.

How much can I make with an online direct-entry MSN degree?

Graduates of online direct-entry MSN programs can expect strong earning potential, especially as they move into advanced practice or leadership roles. Salaries vary based on specialization, experience, and location, but MSN-prepared nurses typically earn significantly more than those with only a bachelor's or associate degree in nursing.

• Nurse Practitioners (NPs): Median annual salary of around $128,490 as of 2023, according to the U.S. Bureau of Labor Statistics (BLS).
• Nurse Educators: Average salary of approximately $94,980, depending on the academic setting and region.
• Nurse Administrators and Managers: Median salary of about $104,830, with higher earnings in large healthcare systems.
• Clinical Nurse Leaders and Specialists: Earnings typically range from $90,000 to $120,000+, depending on specialty and setting.
• Public Health Nurses: Salaries vary widely but generally range from $70,000 to $100,000, with opportunities for advancement in government or nonprofit sectors.

Overall, an MSN degree—whether earned online or on-campus—offers a solid return on investment, opening doors to higher-paying, stable, and impactful careers in healthcare.

List of the Best Online Direct Entry MSN Programs for Non-Nurses for 2025

1. Elmhurst University

Elmhurst University offers an online Master’s Entry in Nursing Practice (MENP) program designed for students with bachelor's degrees in other fields who want to transition to the nursing profession. Through this rigorous, full-time program, you can earn your MSN in just 20 months while preparing to sit for the National Council Licensure Examination for Registered Nurses (NCLEX-RN) and the clinical nurse leader (CNL) certification exam.

All coursework is 100% online, but you will need to do nursing clinicals close to your local area and attend one on-campus residency. This MENP program will prepare you for your new role providing direct patient care and as a clinical nurse leader. You will be able to shift to a nurse practitioner role through post-graduate certification programs or by pursuing a doctor of nursing (DNP) degree.

• Location: Elmhurst, IL
• Program Length: 20 months
• Credits Required: 71 credit hours and 810 clinical hours
• Cost Per Credit Hour: $845.07
• Accreditation: Commission on Collegiate Nursing Education (CCNE)

2. University of South Carolina

University of South Carolina offers a Master's Entry to Practice Nursing (MEPN) designed to prepare non-nurse baccalaureate-prepared individuals to enter the nursing profession as master's degree graduates. This program is not exclusively an online program as it offers a combination of synchronous face-to-face classes, online courses, and required clinical experiences. 

To get admitted into the program, you need to have completed pre-requisite courses in anatomy, microbiology, chemistry, and human growth and development. The program boasts a 100% NCLEX pass rate.

• Location: Columbia, SC
• Program Length: 5 semesters
• Credits Required: 68
• Estimated Total Cost: $44,455 (In-State); $86,020 (Out-of-State)
• Accreditation: Southern Association of Colleges and Schools Commission on Colleges (SACSCOC); Commission on Collegiate Nursing Education (CCNE)

3. Marquette University

Marquette University offers a Direct Entry Master of Science in Nursing program that allows you to leverage your non-nursing bachelor's degree to transition into a nursing career in as little as five semesters. You may also elect to enroll in an extended option to complete your coursework over an eight-semester timeframe.

This Direct Entry MSN program is offered from two locations within Wisconsin: the main campus in Milwaukee, and a satellite site in Pleasant Prairie. Milwaukee cohorts complete coursework following a predominantly in-person learning modality. Pleasant Prairie cohorts, on the other hand, offer didactic coursework predominantly online.

Marquette University's Direct Entry MSN students have achieved an NCLEX-RN score of 93.86% in 2024.

• Location: Milwaukee, WI | Pleasant Prairie, WI
• Program Length: 5-8 semesters
• Credits Required: 75
• Cost of Program: $67,000-$69,000
• Accreditation: Higher Learning Commission (HLC); CCNE

4. Rush University

Rush University offers a Generalist Entry Master’s in Nursing (MSN) for Non-Nurses: Clinical Nurse Leader program that allows students with a bachelor's degree in another field to pursue nursing and focus on clinical leadership. This GEM program requires a minimum of 74 term hours of didactic instruction and 1,120 clock hours of clinical instruction. Upon completion, you are eligible to sit for both the NCLEX-RN and the CNL  

The coursework has certain online components, but most of it is delivered in-person. 

• Location: Chicago, IL
• Program Length: 2-3 years
• Credits Required: 74 credits and 1,120 clinical hours
• Tuition Per Credit: $1,131
• Accreditation: Higher Learning Commission (HLC), CCNE

5. Herzing University

Herzing University offers an online MSN Direct Entry program, with 100% online didactic classes, including both on-demand and real-time learning with flexible scheduling. The degree program provides students with fundamental knowledge and skills in pathophysiology & pharmacology, scholarly practice, mental health nursing, nursing informatics and healthcare technology, and population health, among others. 

Through the program, you can build a foundation to pursue an advanced specialty in a future post-master's certificate program. Transfer credit, stackable credentials, and adaptive learning technology build a faster pathway to a higher education with Herzing. You can also earn dual credit towards a Doctor of Nursing Practice (DNP).

• Location: Birmingham, AL
• Program Length: 20-24 months
• Credits Required: 60-77
• Cost: $790 per credit
• Accreditation: HLC, CCNE

How long does it typically take to complete online direct entry MSN programs?

The typical completion time for online direct entry MSN programs ranges from 20 to 36 months, depending on the program structure, your prior education, and whether you study full-time or part-time. These programs are designed for students with non-nursing bachelor’s degrees, so they begin with foundational nursing coursework and clinical training before progressing to advanced graduate-level content.

• Accelerated full-time programs, or the shortest online MSN programs for non-nurses, can take as little as 20 to 24 months.
• Part-time or flexible pace options may take up to 3 years or more.
• Many programs include pre-licensure training and prepare students to sit for the NCLEX-RN before advancing to MSN coursework.
• Clinical rotations and in-person intensives are typically required, even in online formats, and can affect overall program length.

Ultimately, the duration depends on your availability and the specific school’s curriculum design, but these programs offer a streamlined path to advanced nursing practice for career changers.

What are the prerequisites for enrolling in online direct entry MSN programs for non-nurses?

Online direct entry MSN programs are specifically designed for students with a non-nursing bachelor’s degree, but there are still several key prerequisites to meet before applying. Much like a data analytics bootcamp online, where foundational skills are required before diving into advanced training, these nursing programs ensure you’re prepared for the intensity of graduate-level education and clinical work.

• Bachelor’s Degree in a Non-Nursing Field: Most programs require a regionally accredited bachelor’s degree, often in fields like biology, psychology, or public health—but all majors are typically considered.
• Prerequisite Coursework: Common required courses include anatomy and physiology, microbiology, statistics, nutrition, and human development. These may need to be completed before starting the program or as part of the initial curriculum.
• Minimum GPA: A cumulative GPA of 2.75 to 3.0 is typically required, though some programs may consider applicants with lower GPAs if they show academic or professional potential.
• Letters of Recommendation: Usually 2–3 letters from academic or professional references who can speak to your readiness for graduate study and healthcare work.
• Personal Statement or Essay: A written statement explaining your interest in nursing, career goals, and why you’re pursuing an MSN through a direct-entry path.
• Resume/CV: Highlighting any relevant work, volunteer experience, or coursework in healthcare or related fields.
• Interview: Some programs may require a virtual or phone interview as part of the admissions process.
• Background Check and Immunizations: Required before clinical placements begin, in line with healthcare industry standards.

These prerequisites ensure students are academically prepared and personally committed to transitioning into a demanding but rewarding nursing career. Even the easiest direct entry MSN programs have some of these admission requirements.

What is the average cost of online direct entry MSN programs for non-nurses?

The cost of online direct entry MSN programs for non-nurses can vary widely based on the school, location, and program length. On average, you can expect to pay between $60,000 and $100,000 for the full program. This estimate typically includes tuition, fees, and some course materials, but may not cover travel or housing for in-person clinicals or campus intensives. 

For comparison, just as freight broker training online programs charge for specialized professional instruction but vary based on duration and resources, MSN programs also differ:

• Public universities may offer lower tuition for in-state residents, ranging from $50,000 to $80,000.
• Private institutions often fall between $80,000 and $100,000 or more, especially for highly ranked or accelerated programs.
• Additional costs may include background checks, health screenings, uniforms, and licensing exam fees (e.g., NCLEX-RN).
• Financial aid, scholarships, and payment plans are often available, and some employers may offer tuition reimbursement for future nursing professionals.

While the upfront cost may be high, many graduates see a strong return on investment through higher earning potential and faster career advancement in advanced nursing roles. You can also look into the cheapest online MSN programs for affordable, budget-free options. 

If you are considering an advanced nursing degree, it is important that you understand the potential earning power of your specialization so you can calculate your return on investment. The chart below shows the average annual wage for certain types of RNs, including graduate-level nurses, offering a glimpse into the financial benefits of this educational pathway and allowing you to assess whether it's financially worth it.

What are the financial aid options for students enrolling in online direct entry MSN programs for non-nurses?

Students enrolling in online direct entry MSN programs for non-nurses have multiple financial aid options to help manage tuition costs. Most accredited programs qualify for federal financial aid, which is accessed by submitting the Free Application for Federal Student Aid (FAFSA). Similarly, students in specialized programs, like a dental assistant to dental hygienist bridge program online, can take advantage of these same funding avenues.

• Federal Student Loans: Available to graduate students and often the first line of financial support.
• Scholarships and Grants: Offered by universities, private organizations, nursing associations (like the American Association of Colleges of Nursing), and healthcare employers.
• Employer Tuition Reimbursement: Some students working in healthcare or related industries may qualify for tuition support through their employers.
• State and Institutional Aid: Depending on your residency and the school, additional aid may be available through state grants or institutional need- or merit-based scholarships.
• Loan Forgiveness Programs: After graduation, programs like the Public Service Loan Forgiveness (PSLF) or NURSE Corps Loan Repayment can help reduce debt for those working in underserved or nonprofit settings.

Exploring all available financial aid options early in the application process is essential to making your MSN education more affordable and manageable.

What courses are typically included in online direct entry MSN programs for non-nurses?

Online direct entry MSN programs for non-nurses are structured in two main phases: pre-licensure coursework (to prepare for RN licensure) and graduate-level MSN coursework (to build advanced nursing skills). These programs blend theoretical knowledge with hands-on clinical training to ensure students are fully prepared for both licensure and advanced practice.

Students who are exploring other professional development options may also consider programs like landscaping technology certification courses online, which offer specialized technical skills in a completely online format.

Pre-Licensure Coursework (Foundational Nursing)

• Anatomy and Physiology
• Microbiology
• Pharmacology
• Foundations of Nursing Practice
• Health Assessment
• Pathophysiology
• Nursing Ethics and Law
• Clinical Practicum and Simulations

MSN-Level Coursework (Advanced Practice and Leadership)

• Advanced Health Assessment
• Advanced Pharmacology
• Advanced Pathophysiology
• Evidence-Based Practice
• Leadership and Management in Nursing
• Healthcare Policy and Advocacy
• Population and Community Health Nursing
• Specialty Courses (e.g., Family Nurse Practitioner, Nurse Educator, Clinical Nurse Leader)
• Capstone Project or Thesis
• Advanced Clinical Practicums

This combination of courses equips students with both the clinical competencies to provide direct patient care and the critical thinking skills needed for leadership, education, or specialty roles in today’s complex healthcare environment.

The table below shows the employment projections data for nurse practitioners, nurse anesthetists, and nurse midwives. It would help you understand why NPs are considered to be the "best job" for 2025, not just in healthcare, but overall in the country.

How can I choose the best online direct entry MSN program for non-nurses?

Choosing the right direct entry MSN programs online as a non-nurse involves careful evaluation of your goals, learning style, and professional aspirations. With many options available, it’s important to look beyond just cost and convenience to ensure the program truly supports your career transition into nursing.

Here are key factors to consider:

• Accreditation: Make sure the program is accredited by the Commission on Collegiate Nursing Education (CCNE) or Accreditation Commission for Education in Nursing (ACEN) to ensure quality and eligibility for licensure.
• NCLEX-RN Pass Rates: High first-time pass rates on the NCLEX-RN are a good indicator of a program’s effectiveness in preparing students for licensure.
• Program Format and Flexibility: Look for programs that match your schedule—whether you need full-time, part-time, or accelerated options—and ensure the online delivery includes adequate support.
• Clinical Placement Support: Some programs assist with arranging clinical rotations in your area, while others require you to secure placements independently.
• Specialization Options: If you’re aiming for a particular role (like Family Nurse Practitioner or Nurse Educator), choose a program that offers the relevant track.
• Cost and Financial Aid: Compare total tuition, available scholarships, and financial aid packages to assess overall value.
• Reputation and Graduate Outcomes: Research alumni reviews, job placement rates, and employer partnerships to gauge long-term career support.
• Faculty Expertise and Student Support: Strong, experienced faculty and accessible academic advising can make a significant difference in your learning experience.

By thoroughly researching these aspects, you can select a program that aligns with your needs and sets you up for success in your nursing career.

Passing the NCLEX-RN exam is a critical milestone in the nursing profession. This chart provides insight into the typical success rates for first-time takers, broken down by their nursing degree level, offering a valuable perspective on program effectiveness.

What are the differences between on-campus and online direct entry MSN programs for non-nurses?

While both on-campus and online direct entry MSN programs lead to the same degree and nursing licensure, they differ in structure, delivery, and flexibility—making each format better suited for different types of learners and lifestyles.

Online Programs

• Flexible Scheduling: Coursework can often be completed asynchronously, allowing students to study around work or family obligations.
• Remote Learning: Lectures, discussions, and assignments are delivered through an online platform, minimizing the need for daily commutes.
• In-Person Requirements Still Apply: Students must still complete in-person clinical rotations and sometimes attend on-campus intensives or skills labs.
• Best For: Career changers, working adults, or those who live far from nursing schools and need geographic flexibility.

On-Campus Programs

• Structured Learning Environment: Fixed schedules and face-to-face instruction offer more daily structure and direct interaction with faculty and peers.
• Immediate Access to Campus Resources: Labs, libraries, academic advising, and student support services are readily accessible.
• More In-Person Collaboration: Encourages real-time collaboration, networking, and hands-on practice with classmates.
• Best For: Students who thrive in a traditional classroom setting and can commit to being on campus regularly.

Both formats require clinical hours, NCLEX-RN preparation, and graduate-level coursework, but the choice depends on your personal preferences, lifestyle, and learning needs.

What is the job outlook for graduates of online direct entry MSN programs for non-nurses?

The career outlook for MSN‑prepared nurses entering advanced roles is exceptionally strong—driven by physician shortages, an aging population, and an ongoing national nursing shortage. Here’s what recent data shows:

• According to the United States Bureau of Labor Statistics, the employment of nurse practitioners (NPs), which is a key role for direct‑entry MSN graduates, is projected to grow by 46% from 2023 to 2033, making it one of the fastest‑growing professions in the U.S.
• About 31,900 openings for nurse practitioners, nurse midwives, and nurse anesthetists are projected annually from 2023 to 2033. Many of these openings result from an increase in the demand for healthcare services.
• Healthcare overall added 51,000 jobs in April 2025, with NPs ranked as the “best job in America” by U.S. News & World Report due to high demand, stability, and income potential.
• Nurse practitioners, clinical nurse leaders, and other advanced nursing roles are increasingly in demand as healthcare systems rely on APRNs to fill gaps in primary care and specialty services.
• A persistent global nursing shortage adds to the demand for MSN‑prepared candidates. In many countries—including the U.S. and Canada—nursing vacancies remain high, and workforce inflow struggles to keep pace.

Pursuing an online direct‑entry MSN places you on track for advanced roles with strong job prospects and stability. Whether you choose to become an NP, CNL, nurse educator, or public health nurse, demand in these areas is consistently increasing. The investment in your education positions you well in a healthcare system eager for skilled leaders and providers.

You can check out the different types of master degree in nursing so you can evaluate your options and the career you want to get into.

What career paths are available for graduates of online direct entry MSN programs for non-nurses?

Graduates of online direct entry MSN programs for non-nurses are well-prepared to enter a wide range of advanced nursing and healthcare leadership roles. These programs equip students with the clinical knowledge, leadership skills, and credentials needed to pursue specialized positions that go far beyond entry-level nursing.

Here are some common career paths:

• Nurse Practitioner: Provide primary or specialty care in clinics, hospitals, or private practices. Specializations may include Family NP, Adult-Gerontology NP, or Psychiatric-Mental Health NP.
• Clinical Nurse Leader (CNL): Oversee patient care coordination and quality improvement within healthcare teams.
• Nurse Educator: Teach future nurses in academic or clinical settings, develop curricula, and contribute to training programs.
• Public Health Nurse: Work in communities to improve population health, run outreach programs, and influence health policy.
• Nurse Administrator or Manager: Lead nursing teams, manage budgets, and improve care delivery systems in hospitals or long-term care facilities.
• Case Manager or Care Coordinator: Help patients navigate complex healthcare systems, ensuring efficient and effective care.
• Informatics Nurse Specialist: Use data and technology to improve patient care, system efficiency, and clinical decision-making.

With an MSN degree, graduates also lay the foundation for future opportunities such as pursuing a Doctor of Nursing Practice (DNP) or moving into executive healthcare leadership roles. You can also look into accelerated DNP programs if you want a fast-track option towards earning a more advanced degree.

Here's What Graduates Have to Say About Their Online Direct Entry MSN Degree

Other Things You Should Know About the Best Online Direct Entry MSN Programs for Non-nurses

Can I work while enrolled in an online direct-entry MSN program?

It depends on the program and your personal schedule. These programs are often intensive, especially during clinical rotations and pre-licensure phases. Some students manage part-time work, but full-time employment is generally discouraged. Online flexibility helps, but the academic load can be demanding.

Will I be eligible to sit for the NCLEX-RN after completing a direct-entry MSN program?

Yes, most direct-entry MSN programs include the necessary pre-licensure coursework and clinical training to qualify you for the NCLEX-RN exam. You typically take the exam midway through the program before beginning graduate-level coursework. Always verify licensure eligibility with the specific program and your state board of nursing.

Do online direct-entry MSN programs accept students with non-science majors?

Yes, many programs accept students from non-science backgrounds such as business, psychology, or liberal arts. However, you may be required to complete specific science prerequisites before starting the program. Check each school’s admissions requirements for details.

Can I specialize in a particular area of nursing with a direct-entry MSN?

Some programs offer specialty tracks such as Family Nurse Practitioner (FNP), Nurse Educator, or Public Health Nursing. You typically choose a specialty during the MSN portion of the program. Be sure to choose a school that offers your desired area of focus. Other programs just offer a general MSN and you can just specialize or choose an area of focus through a post-graduate certification program.